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N-acetyl glucosamine is an amino acid sugar that is naturally found in the body and is distinct from other forms of glucosamine. The supplemental form comes from shellfish. It is a building block for the connective tissue that holds cells together and helps to build cartilage, ligaments and tendons; therefore, it is great for joint health. N-acetyl glucosamine aids digestion by binding to lectins, which can cause gastrointestinal discomfort.