ArthroZyme Plus Joint & Muscle

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Clinically studied nutrients for joint support…in as little as 7 days*

Joint discomfort and stiffness can rob you from enjoying the things you love…gardening, walking with a friend, playing with your grandkids. And while there are many joint formulas out there, most just offer temporary relief. ArthroZyme Plus goes beyond “ordinary” joint formulas to address four primary sources of joint discomfort in as little as 7 days.*

True Results:

  • Promotes joint health*
  • Supports the health of your cartilage*
  • Supports the health of your joints*

How ArthroZyme Plus Works for You

Most joint formulas on the market today only offer temporary relief because they solely focus on one aspect of joint health—your inflammatory response. But to experience lasting relief from joint discomfort and stiffness, you need to go beyond your inflammatory response and address the primary source of the discomfort. And, in most cases the culprits are likely fibrin, bradykinin, and the enzymes MMP-3 or 5-LOX.*

Fibrin: Throughout your life, your joints go through wear and tear. Each time you stress your joints, your body sends “repair proteins” called fibrins to the spot. Normally, these proteins form a protective web around the area, do their repair work, and then dissolve. But sometimes the fibrins don’t dissolve. Help support joint health with ArthroZyme Plus. The irritation eventually leads to discomfort and stiffness.*

Bradykinin: Like fibrin, bradykinin is produced by the body when there’s a bump or a knock to the body. Bradykinin makes the blood vessels in muscles and around joints dilate (get wider), allowing more blood to get to the area. ArthroZyme Plus can help support joint health.*

MMP-3 Enzyme: As you get older, your body produces a chemical called MMP-3. It’s unclear why your body produces more and more MMP-3 as you get older. But research has shown that MMP-3 can have a negative impact on the health of your cartilage.*

ArthroZyme Plus is an incredibly powerful combination of five scientifically studied ingredients—at researched dosages.Starting in as little as 7 days, the nutrients in ArthroZyme Plus begin to maintain the health of your joints. Each daily dose includes:*

  1. 5-LOXIN® Boswellia (250 mg)

    Boswellia has been used for centuries by natives of India and China to support joint health. Research shows 5-LOXIN—the form of boswellia used in ArthroZyme Plus—is a powerful weapon against 5-LOX.*

    5-LOXIN also protects your cartilage by reducing production of MMP-3. In studies, 250 mg of 5-LOXIN—the same amount in ArthroZyme Plus—was so effective that it reduced MMP-3 and promote joint health in just 7 days.*

  2. Serratiopeptidase (10 mg)

    This potent enzyme is produced by silkworms and dissolves both fibrin and bradykinin. When silkworms bust out of their cocoons to become moths, they produce this natural enzyme to eat away at the proteins holding the cocoon together. These proteins are remarkably similar to fibrin.*

    Serrapeptase in ArthroZyme Plus is a highly concentrated, pure form of serratiopeptidase, that’s been shown to maintain joint health. You get the research dose of 10 mg of serrapeptase in ArthroZyme Plus to promote joint health.*

  3. Bromelain (400 mg)

    This extract of pineapple helps to stop fibrin from building up in the bloodstream and being deposited into joints and damaged tissue. Research shows 400 mg of bromelain daily can support joint health—and that’s the exact amount you get in ArthroZyme Plus.*

  4. Vitamin D3 (1,000 IU)

    Researchers have discovered that people with insufficient vitamin D levels have lower volumes of knee cartilage. However, when vitamin D levels are increased, positive changes occur in the cartilage volume. ArthroZyme Plus contains 1,000 IU of vitamin D3—your body’s preferred form of vitamin D—to boost your protection against the loss of cartilage.*

  5. Zinc (15 mg)

    This powerful trace mineral supports muscle comfort and flexibility. Preliminary research indicates zinc may regulate certain receptors which affect pain sensing neurons in the central nervous system.*

Research Results

5-LOXIN® Boswellia to Reduce Discomfort*

In a double-blind, placebo controlled study, 5-LOXIN was shown to significantly improve physical function and ease discomfort in as little as 7 days.* Read More

Serratiopeptidase to Ease Swelling*

A double-blind study with serratiopeptidase found that the enzyme reduced swelling by 50% after just 3 days. Read More

Bromelain to Improve Physical Function

An open study found that bromelain reduced discomfort and stiffness and improved physical function after 1 month.* Read More

NOTE: Enzymes like serratiopeptidase have a blood-thinning effect due to their action on fibrin, so if you take coumadin or prescription blood-thinners consult your healthcare provider before taking ArthroZyme Plus

Research Results

Featured Ingredient: Boswellia

In a double-blind, randomized, placebo controlled study, subjects received either 100 mg or 250 mg of 5-LOXIN® daily or a placebo for 90 days. Significant improvements in pain score and functional ability were recorded in the treatment group supplemented with 250 mg 5-LOXIN in as little as 7 days after the start of treatment.*

And, within 90 days, the group that received 250 mg of 5-LOXIN showed 46.4% reduction in MMP-3. In addition, discomfort was reduced by 75%, physical function improved 55%, and stiffness was reduced by 66%.1*

Featured Ingredient: Serratiopeptidase

A double-blind study reviewed the effect of serratiopeptidase on discomfort in 66 subjects. Study participants were divided into three groups. One group received serratiopeptidase. The other two groups were assigned to bed rest and leg elevation, with one group using ice, and the other not using ice. In the group that received serratiopeptidase, swelling decreased by 50% by day three. No reduction in swelling occurred in the bed rest groups. In addition, the serratiopeptidase group saw their discomfort reduced more quickly than the other groups.2*

In another double-blind, placebo-controlled study 193 participants were divided into two groups. One group received 10 mg of serratiopeptidase 3 times a day. The second group received a placebo. Treatment lasted 7-8 days. After 3-4 days, significant symptom regression was observed in the group receiving serratiopeptidase. And while patients in both treatment groups experienced a significant reduction in symptoms after 7-8 days, the response was more marked in those subjects that received serratiopeptidase. The researchers concluded that serratiopeptidase promotes a healthy inflammatory response and acts rapidly.3*

Featured Ingredient: Bromelain

An open, 1-month study, of 77 volunteers between the ages of 25 and 50 examined bromelain’s impact on discomfort and stiffness. The study participants were divided into two groups. One group received 200 mg of bromelain per day. The other group was given 400 mg daily. At the end of the trial both groups saw improvement, but the group receiving 400 mg each day saw the best results. In that group, discomfort was reduced by more than 58%, stiffness declined by over 65% and physical function improved by 58%.4*

Featured Ingredient: Vitamin D3

In one study, researchers randomly selected 880 people between 50 and 80 years of age to evaluate vitamin D levels and knee cartilage volume. MRI analysis revealed that winter sunlight exposure and serum 25(OH)D levels were both associated with higher cartilage volumes. (Serum 25(OH)D levels are used to measure a person’s vitamin D level.) At the same time, lower vitamin D levels were associated with lower cartilage volumes and joint space narrowing.5*

Featured Ingredient: Zinc

The association between levels of trace elements in the blood and tender points in the body was evaluated in 32 adults experiencing joint discomfort and stiffness. Researchers found that low levels of zinc were associated with more tender points and joint discomfort.6*

A study with mice indicated that zinc may work against joint discomfort by regulating certain receptors that affect discomfort-sensing neurons in the central nervous system.7*


1 Sengupta K et al. 2008;10(4):R85.

2 Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2.

3 J Int Med Res. 1990 Sep-Oct;18(5):379-88.

4 Phytomedicine. 2002 Dec;9(8):681-6.

5 Ding C et al. 2009 May;60(5):1381-9.

6 Rheumatol Int. 2008 Sep;28(11):1117-21

7 Nat Neurosci. 2011 Jul 3;14(8):1017-22.

Supplement Facts:

Serving size: 2 capsules
Servings per bottle: 30 (1 month supply)
Each bottle contains: 60 Capsules

Suggested Use: Adults take up to 2 capsules daily on an empty stomach. Do not exceed a dose of 30mg of serratiopeptidase per day unless directed by a healthcare professional.

NOTE:  If you are pregnant, nursing or on medication, consult your physician prior to taking.

Each serving contains: Amount Per Serving % Daily Value
Vitamin D3 (as cholecalciferol) 25 mcg 125%
Zinc (as zinc glycinate chelate) 15 mg 136%
Bromelain (from pineapple) 400 mg *
Boswellia Gum Resin Extract^ 250 mg *
Serratiopeptidase 10 mg *
*Daily Value (DV) not established    

Other Ingredients: Vegetarian capsule (cellulose), maltodextrin, silica, vegetable stearate and microcrystalline cellulose.

^5-Loxin® is a registered trademark of PL Thomas & Co Inc. International patents pending.