Featured Ingredient: Nattokinase
A randomized, double-blind, placebo-controlled human clinical trial explored the impact of nattokinase on heart health. 73 study participants with blood pressure concerns were divided into two groups. One group ingested 2,000 FU (the equivalent of 100 mg) of nattokinase orally daily for 8 weeks. The other group received a placebo. Researchers found that the group that received nattokinase supplementation experienced a reduction in both systolic and diastolic blood pressure.1*
Featured Ingredient: Grape Seed Extract
In an 8-week, double-blind, randomized control trial of post-menopausal women, researchers explored the impact of grape seed extract (GSE) on platelet function. Researchers divided the 17 study participants into two groups. One group received 400 mg of grape seed extract. The other group was given a placebo. At the conclusion of the trial, the results showed that the group that was given grape seed extract experienced prolonged occlusion (closure times) after ADP-stimulation. This effect was significant on day 1, increasing ADP-stimulated closure time by 23.7% after 2 hours and 14.2% after 6 hours, post consumption. In addition, GSE, but not placebo, was associated with a strong trend for increasing ADP-stimulated closure time after 8 weeks.2*
A randomized, placebo-controlled, study investigated the impact of grape seed extract on oxidized LDL cholesterol levels. 61 healthy subjects were divided into three groups. One group received 200 mg of grape seed extract daily. A second group received 400 mg of grape seed extract per day. The third group received a placebo. After 12 weeks, researchers discovered that the group that was given 400 mg of grape seed extract significantly reduced oxidized LDL cholesterol.3*
Featured Ingredient: Green Tea Leaf Extract
A 2-week study of 20 young healthy smokers explored the impact of green tea consumption on endothelial health and flow-mediated dilation (FMD). The adults consumed 8 grams of green tea each day containing 3.2% EGCG (the equivalent of 256 mg daily of EGCG.) At the conclusion of the study, researchers found improved endothelial function and FMD compared to baseline.4*
The acute effect of green tea consumption was investigated in a study of 14 healthy smokers. On three separate occasions, trial subjects took either: 6 grams of green tea, 125 mg of caffeine, or hot water. Flow-mediated dilation (FMD) of the brachial artery was measured before each intervention and 30, 90, and 120 minutes afterward. Researchers found that flow mediated dilation increased significantly with the tea, indicating green tea’s beneficial effect on endothelial function.5*
A double-blind, placebo-controlled study was conducted with 240 Japanese men and women. Researchers divided the subjects into two groups. One group received 583 mg daily of catechins, comprised of 17.2% EGCG (the equivalent of 100 mg of EGCG) for 12 weeks. The control group received 96 mg of catechins per day. At the end of the trial, researchers discovered that the group that received the higher dose of catechins had better support for healthy LDL cholesterol and systolic blood pressure than control. The larger catechins dose also resulted in a greater decrease in body weight, BMI, body fat ratio, body fat mass, waist circumference, hip circumference, visceral fat, and subcutaneous fat more than the control.6*
Featured Ingredient: Alpha Lipoic Acid
In a 4-week randomized control of people with blood sugar concerns, the impact of ALA on oxidative stress was explored. A total of 14 patients were randomly assigned to the two groups.*
One group received 400 mg daily of alpha lipoic acid. The other received a placebo. At the end of the study researchers found reduced markers of oxidative stress and improved HDL cholesterol in the group that was given ALA.7*
1 Kim JY et al. 2008 Aug;31(8):1583-8.
2 Shenoy SF et al. 2007;121(3):431-2. Epub 2007 Oct 24.
3 J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):174-82.
4 Circ J. 2006 Aug;70(8):1052-7.
5 Alexopoulos N et al. 2008 Jun;15(3):300-5.
6 Nageo T et al. 2007 Jun;15(6):1473-83.
7 Arch Gerontol Geriatr. 2009;49 Suppl 1:129-33.